The genomics revolution has led to the generation of an enormous amount of data on the composition, regulation, and physiology of cellular networks. There is a need to integrate this information into a computational framework so that testable predictions can be made with an accounting of the complexity inherent in cellular systems.
Systems biology has emerged as a paradigm to integrate these data in an effort to understand properties of cells that emerge from the collective activity of sub‐cellular processes.
We will discuss some of the fundamental principles of this field as well as some of the exciting advances in tackling challenges in human health including cancer, cardiovascular disease, and infectious disease, as well as societal challenges like the development of bioenergy.
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